Functional properties of dietary quercetin in cardiovascular health and disease

Author:

Xu Kuo12,Qu Liqun12,Li Hui12,Ren Xia12,Yan Ning3ORCID,Fu Xianjun12

Affiliation:

1. Research Institute for Marine Traditional Chinese Medicine, The SATCM's Key Unit of Discovering and Developing New Marine TCM Drugs, Key Laboratory of Marine Traditional Chinese Medicine in Shandong Universities, Shandong Engineering and Technology Research Center on Omics of Traditional Chinese Medicine Shandong University of Traditional Chinese Medicine Jinan China

2. Qingdao Academy of Chinese Medical Sciences Shandong University of Traditional Chinese Medicine, Qingdao Key Laboratory of Research in Marine Traditional Chinese Medicine, Qingdao Key Technology Innovation Center of Marine Traditional Chinese Medicine's Deep Development and Industrialization Qingdao China

3. Plant Functional Component Research Center Tobacco Research Institute of Chinese Academy of Agricultural Sciences Qingdao China

Abstract

AbstractThe increasing incidence of cardiovascular diseases has resulted in an escalating need for natural dietary supplements with cardioprotective properties. This review provides a thorough analysis of laboratory and clinical studies conducted on dietary quercetin, a widely available flavonoid, and its influence on the management of cardiovascular health and disease. The references cited in this review were obtained from reputable databases, including SciFinder, Web of Science, and ClinicalTrials.gov, with a specific focus on the period spanning from 1999 to 2023 pertaining to this subject matter. Notably, a bibliometric approach was used to analyze the bibliometric attribute trends of the research on quercetin associated with vascular health for the first time. Numerous investigations conducted on animal and human subjects at different phases of cardiac illness have consistently shown that the administration of quercetin substances improves cardiac function, suggesting the potential efficacy of quercetin in the management of heart disease. Evidently, the consumption of quercetin through dietary sources holds promise in conferring significant cardiovascular benefits through physiological mechanisms and biochemical signaling pathways, thus positioning it as a promising dietary contender for the prevention of cardiovascular disorders. Renewable food resources, including lovage leaves, elderberry, and radish leaves, which are abundant in quercetin, exhibit significant potential for the development and production of novel healthcare products with the objective of preventing cardiovascular disorders. This review is anticipated to provide valuable insights for the advancement of cardioprotective functional foods in the foreseeable future.

Funder

Natural Science Foundation of Shandong Province

Publisher

Wiley

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