Evaluation of high-capacity cation exchange chromatography for direct capture of monoclonal antibodies from high-titer cell culture processes

Author:

Tao Yinying1,Ibraheem Aladein1,Conley Lynn1,Cecchini Douglas2,Ghose Sanchayita1

Affiliation:

1. Department of Process Biochemistry; Biogen Idec; 5000 Davis Drive Research Triangle Park North Carolina

2. Department of Process Biochemistry; Biogen Idec; Cambridge Massachusetts

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference29 articles.

1. Arunakumari A 2006

2. Improved downstream process design for human monoclonal antibody production;Arunakumari;Biopharm Int,2007

3. Advances in non-protein A purification processes for human monoclonal antibodies;Arunakumari;Biopharm Int,2009

4. Defining your product profile and maintaining control over it, part 2: Challenges of monitoring host cell protein impurities;Champion;BioProcess Int,2005

5. Cation exchange chromatography provides effective retrovirus clearance for antibody purification processes;Connell-Crowley;Biotechnol Bioeng,2012

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