Affiliation:
1. Department of Pathology St. Jude Children's Research Hospital Memphis Tennessee USA
2. Department of Computational Biology St. Jude Children's Research Hospital Memphis Tennessee USA
3. Department of Oncology St. Jude Children's Research Hospital Memphis Tennessee USA
Abstract
AbstractChildhood melanoma is a rare and biologically heterogeneous pediatric malignancy. The differential diagnosis of pediatric melanoma is usually broad, including a wide variety of spindle cell or epithelioid neoplasms. Different molecular alterations affecting the MAPK and PI3K/AKT/mTOR pathways, tumor suppressor genes, and telomerase reactivation have been implicated in melanoma tumorigenesis and progression. Here, we report a novel MED15::ATF1 fusion in a pediatric melanoma with spitzoid features and an aggressive clinical course.