Affiliation:
1. College of Food Science and Technology Guangdong Ocean University Zhanjiang 524088 P. R. China
2. Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety Zhanjiang 524088 P. R. China
3. Guangdong Province Engineering Laboratory for Marine Biological Products Zhanjiang 524088 P. R. China
4. Guangdong Provincial Engineering Technology Research Center of Marine Food Zhanjiang 524088 P. R. China
5. Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution Zhanjiang 524088 P. R. China
Abstract
AbstractTo investigate the efficacy of anserine on antiobesity, C57BL/6 mice are orally administered with a high‐fat diet (HFD) and different doses of anserine (60, 120, and 240 mg/kg/day) for 16 weeks. Body weight, lipid, and epididymal fat content in mice are measured, and their liver damage is observed. The results display that the body weight, epididymal fat content, and low‐density lipoprotein cholesterol (LDL‐C) content in anserine groups are decreased by 4.36–18.71%, 7.57–35.12%, and 24.32–44.40%, respectively. To further investigate the antiobesity mechanism of anserine, the expression of SREBP‐1, NLRP3, NF‐κB p65 (p65), and p‐NF‐κB p65 (p‐p65) proteins in the liver and peroxisome proliferator‐activated receptor gamma coactivator 1α (PGC1‐α) and UCP‐1 proteins in brown adipose tissue (BAT) is analyzed by Western blot. Results show that anserine can significantly decrease the expression of the NLRP3, p65, p‐p65, and the SREBP‐1 proteins and increase the expression of the PGC1‐α and UCP‐1 proteins. This study demonstrates that anserine lowered blood lipids and prevented obesity; its antiobesity mechanism may be related to the activation of brown fat by inflammation.