Photoperiod‐Dependent Effects of Grape‐Seed Proanthocyanidins on Adipose Tissue Metabolic Markers in Healthy Rats

Author:

Navarro‐Masip Èlia1ORCID,Manocchio Francesca123ORCID,Rodríguez Romina M.1,Bravo Francisca Isabel1ORCID,Torres‐Fuentes Cristina123ORCID,Muguerza Begoña123ORCID,Aragonès Gerard123ORCID

Affiliation:

1. Nutrigenomics Research Group Department of Biochemistry and Biotechnology Universitat Rovira i Virgili Tarragona 43007 Spain

2. Institute of Health Research Pere Virgili (IISPV) Tarragona 43007 Spain

3. Center of Environmental, Food and Toxicological Technology (TecnATox) Universitat Rovira i Virgili Tarragona 43007 Spain

Abstract

ScopeVariations in photoperiod patterns drive metabolic adaptations in mammals, involving important changes in body weight and adiposity. Moreover, (poly)phenols can help heterotrophs adopt metabolic adaptations to face the upcoming environmental conditions. Particularly, proanthocyanidins from grape‐seeds show photoperiod‐dependent effects on different metabolic parameters. The present study aims to explore whether grape‐seed proanthocyanidin extract (GSPE) consumption differently affects the expression of metabolic markers in WAT (subcutaneous and visceral depots) and BAT in a photoperiod‐dependent manner.Methods and resultsGSPE (25 mg kg−1 day−1) is orally administrated for 4 weeks to healthy rats exposed to three photoperiods (L6, L12, and L18). In WAT, GSPE consumption significantly upregulates the expression of lipolytic genes in all photoperiods, being accompanied by increased serum concentrations of glycerol and corticosterone only under the L6 photoperiod. Moreover, adiponectin mRNA levels are significantly upregulated in response to GSPE regardless of the photoperiod, whereas Tnfα and Il6 expression are only downregulated in L6 and L18 photoperiods but not in L12. In BAT, GSPE upregulates Pgc1α expression in all groups, whereas the expression of Pparα is only increased in L18.ConclusionsThe results indicate that GSPE modulates the expression of important metabolic markers of WAT and BAT in a photoperiod‐dependent manner.

Funder

Universitat Rovira i Virgili

Generalitat de Catalunya

Publisher

Wiley

Subject

Food Science,Biotechnology

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