Affiliation:
1. Shenzhen Key Laboratory of Marine Biotechnology and Ecology College of Life Sciences and Oceanography Shenzhen University Shenzhen Guangdong 518055 China
2. Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen Guangdong 518055 China
3. Shenzhen Bay Laboratory Shenzhen Guangdong 518055 China
4. Chemical Analysis & Physical Testing Institute Shenzhen Center for Disease Control and Prevention Shenzhen Guangdong 518055 China
5. National‐Local Joint Engineering Laboratory of Druggability and New Drug Evaluation National Engineering Research Center for New Drug and Druggability (cultivation) Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical Sciences Sun Yat‐Sen University Guangzhou Guangdong 510000 China
Abstract
ScopeAs a natural dietary low‐molecular‐weight thiol, pantethine helps maintain brain homeostasis and function in Alzheimer's disease (AD) mice. The current study aims to investigate the protective effects and underlying mechanisms of pantethine on the mitigation of cognitive deficits and pathology in a triple transgenic AD mouse model.Methods and resultsCompared to control mice, oral administration of pantethine improve spatial learning and memory ability, relieve anxiety, and reduce the production of amyloid‐β (Aβ), neuronal damage, and inflammation in 3×Tg‐AD mice. Pantethine reduces body weight, body fat, and the production of cholesterol in 3×Tg‐AD mice by inhibiting sterol regulatory element‐binding protein (SREBP2) signal pathway and apolipoprotein E (APOE) expression; lipid rafts in the brain, which are necessary for the processing of the Aβ precursor protein (APP), are also decreased. In addition, pantethine regulates the composition, distribution, and abundance of characteristic flora in the intestine; these floras are considered protective and anti‐inflammatory in the gastrointestinal tract, suggesting a possible improvement in the gut flora of 3×Tg‐AD mice.ConclusionThis study highlights the potential therapeutic effect of pantethine in AD by reducing cholesterol and lipid raft formation and regulating intestinal flora, suggesting a new option for the development of clinical drugs for AD.
Funder
Shenzhen Fundamental Research Program
Subject
Food Science,Biotechnology
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献