Tolypocladium sinense Mycelium Polysaccharide Alleviates Obesity, Lipid Metabolism Disorder, and Inflammation Caused by High Fat Diet via Improving Intestinal Barrier and Modulating Gut Microbiota

Author:

Bai Mingjian1ORCID,Wang Xiaolong2,Liu Dongyang3,Xu Aofeng4,Cheng Hao5,Li Lin1,Zhang Chunjing1

Affiliation:

1. Department of Medical Technology Qiqihar Medical University Qiqihar Heilongjiang 161006 China

2. School of Biomedical Engineering Guangzhou Medical University Guangzhou Guangdong 511436 China

3. First Affiliated Hospital of Heilongjiang University of Chinese Medicine Harbin Heilongjiang 150040 China

4. Special Medical Service Department Section Four People's Liberation Army Strategic Support Force Characteristics Medical Center Beijing 100000 China

5. Qiqihar Medical University Clinical Department Qiqihar Medical University Qiqihar Heilongjiang 161006 China

Abstract

ScopeTolypocladium sinense is a fungus isolated from Cordyceps. Cordyceps has some medicinal value and is also a daily health care product. This study explores the preventive effects of T. sinense mycelium polysaccharide (TSMP) on high‐fat diet‐induced obesity and chronic inflammation in mice.Methods and resultsHere, the study establishes an obese mouse model induced by high‐fat diet. In this study, the mice are administered TSMP daily basis to evaluate its effect on alleviating obesity. The results show that TSMP can significantly inhibit obesity and alleviate dyslipidemia by regulating the expression of lipid metabolism‐related genes such as liver kinase B1 (LKB1), phosphorylated AMP‐activated protein kinase (pAMPK), peroxisome proliferator activated receptor α (PPARα), fatty acid synthase (FAS), and hydroxymethylglutaryl‐CoA reductase (HMGCR) in the liver. TSMP can increase the protein expression of zona occludens‐1 (ZO‐1), Occludin, and Claudin‐1 in the colon, improve the intestinal barrier dysfunction, and reduce the level of serum LPS, thereby reducing the inflammatory response. 16S rDNA sequencing shows that TSMP alters the intestinal microbiota by increasing the relative abundance of Akkermansia, Lactobacillus, and Prevotellaceae_NK3B31_group, while decreasing the relative abundance of Faecalibaculum.ConclusionThe findings show that TSMP can inhibit obesity and alleviates obesity‐related lipid metabolism disorders, inflammatory responses, and oxidative stress by modulating the gut microbiota and improving intestinal barrier.

Funder

Natural Science Foundation of Heilongjiang Province

Publisher

Wiley

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