Affiliation:
1. Department of Medical Technology Qiqihar Medical University Qiqihar Heilongjiang 161006 China
2. School of Biomedical Engineering Guangzhou Medical University Guangzhou Guangdong 511436 China
3. First Affiliated Hospital of Heilongjiang University of Chinese Medicine Harbin Heilongjiang 150040 China
4. Special Medical Service Department Section Four People's Liberation Army Strategic Support Force Characteristics Medical Center Beijing 100000 China
5. Qiqihar Medical University Clinical Department Qiqihar Medical University Qiqihar Heilongjiang 161006 China
Abstract
ScopeTolypocladium sinense is a fungus isolated from Cordyceps. Cordyceps has some medicinal value and is also a daily health care product. This study explores the preventive effects of T. sinense mycelium polysaccharide (TSMP) on high‐fat diet‐induced obesity and chronic inflammation in mice.Methods and resultsHere, the study establishes an obese mouse model induced by high‐fat diet. In this study, the mice are administered TSMP daily basis to evaluate its effect on alleviating obesity. The results show that TSMP can significantly inhibit obesity and alleviate dyslipidemia by regulating the expression of lipid metabolism‐related genes such as liver kinase B1 (LKB1), phosphorylated AMP‐activated protein kinase (pAMPK), peroxisome proliferator activated receptor α (PPARα), fatty acid synthase (FAS), and hydroxymethylglutaryl‐CoA reductase (HMGCR) in the liver. TSMP can increase the protein expression of zona occludens‐1 (ZO‐1), Occludin, and Claudin‐1 in the colon, improve the intestinal barrier dysfunction, and reduce the level of serum LPS, thereby reducing the inflammatory response. 16S rDNA sequencing shows that TSMP alters the intestinal microbiota by increasing the relative abundance of Akkermansia, Lactobacillus, and Prevotellaceae_NK3B31_group, while decreasing the relative abundance of Faecalibaculum.ConclusionThe findings show that TSMP can inhibit obesity and alleviates obesity‐related lipid metabolism disorders, inflammatory responses, and oxidative stress by modulating the gut microbiota and improving intestinal barrier.
Funder
Natural Science Foundation of Heilongjiang Province
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献