Human Breast Milk Exosomal miRNAs are Influenced by Premature Delivery and Affect Neurodevelopment-Reference-Cited by-同舟云学术

Human Breast Milk Exosomal miRNAs are Influenced by Premature Delivery and Affect Neurodevelopment

Published:2024-04-21 Issue:9 Volume:68 Page:
ISSN:1613-4125
Container-title:Molecular Nutrition & Food Research
language:en
Short-container-title:Molecular Nutrition Food Res

Author:

Ma Ling¹^ORCID,Huo Yanyan¹,Tang Qingyuan²,Wang Xiulian¹,Wang Weiqin¹,Wu Dan¹,Li Yicheng¹,Chen Lingyan¹³,Wang Shasha¹,Zhu Yiwen⁴,Wang Wenli⁴,Liu Yuan⁴,Xu Nanjie⁵,Chen Li⁶,Yu Guangjun⁷,Chen Jinjin¹

Affiliation:

1. Department of Child Health Care Shanghai Children's Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200062 China

2. Guangdong Provincial Key Laboratory of Brain Function and Disease Department of Pharmacology Zhongshan School of Medicine Sun Yat‐sen University Guangzhou 510080 China

3. Department of Occupational Therapy Science Nagasaki University Graduate School of Biomedical Science 1‐7‐1 Sakamoto Nagasaki 852‐8520 Japan

4. Department of Food Science & Technology School of Agriculture & Biology Shanghai Jiao Tong University Shanghai 200240 China

5. Department of Anatomy and Physiology Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

6. Department of Orthodontics Shanghai Stomatological Hospital & School of Stomatology Fudan University Shanghai 200001 China

7. School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Abstract

ScopeThis study investigates the exosomal microRNA (miRNA) profiles of term and preterm breast milk, including the most abundant and differentially expressed (DE) miRNAs, and their impact on neurodevelopment in infants.Methods and ResultsMature milk is collected from the mothers of term and preterm infants. Using high‐throughput sequencing and subsequent data analysis, exosomal miRNA profiles of term and preterm human breast milk (HBM) are acquired and it is found that the let‐7 and miR‐148 families are the most abundant miRNAs. Additionally, 23 upregulated and 15 downregulated miRNAs are identified. MiR‐3168 is the most upregulated miRNA in preterm HBM exosome, exhibiting targeting activity toward multiple genes involved in the SMAD and MAPK signaling pathways and playing a crucial role in early neurodevelopment. Additionally, the effects of miR‐3168 on neurodevelopment is confirmed and it is determined that it is an essential factor in the differentiation of neural stem cells (NSCs).ConclusionThis study demonstrates that miRNA expression in breast milk exosomes can be influenced by preterm delivery, thereby potentially impacting neurodevelopment in preterm infants.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/mnfr.202300113

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