Effects of Calorie Restriction and Fasting on Macrophage: Potential Impact on Disease Outcomes?

Author:

Wang Lei1,Wang Rong1,Yu Xiaoyan1,Shi Yuhuan1,Li Shengnan1,Yuan Yongfang1ORCID

Affiliation:

1. Department of Pharmacy, Shanghai 9th People's Hospital Shanghai Jiao Tong University School of Medicine No. 280 Mohe Road Shanghai 201999 China

Abstract

AbstractEnergy restriction, including calorie restriction and fasting, has garnered significant attention for its potential therapeutic effects on a range of chronic diseases (such as diabetes, obesity, and cancer) and aging. Since macrophages are critical players in many diseases, their response to energy restriction may impact disease outcomes. However, the diverse metabolic patterns and functions of macrophages can lead to variability in the effects of energy restriction on macrophages across different tissues and disease states. This review outlines the effects of energy restriction on macrophages in several diseases, offering valuable guidance for future studies and insights into the clinical applications of calorie restriction and fasting.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Food Science,Biotechnology

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