Identification of concurrent STAT3::RARA and RARA::STAT5b fusions in a variant APL case-Reference-Cited by-同舟云学术

Identification of concurrent STAT3::RARA and RARA::STAT5b fusions in a variant APL case

Published:2023-12-28 Issue: Volume: Page:
ISSN:0899-1987
Container-title:Molecular Carcinogenesis
language:en
Short-container-title:Molecular Carcinogenesis

Author:

Tao Tingting¹²,Cen Jiannong¹²,Xu Chao¹²,Chen Yan¹²,Cao Yanglin¹²,Gong Yanlei¹²^ORCID,Zhu Mingqing¹²,Chen Suning¹²,Zhang Qike³,Yao Li¹²

Affiliation:

1. Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, NHC Key Laboratory of Thrombosis and Hemostasis, Department of Haematology The First Affiliated Hospital of Soochow University Soochow University Suzhou Jiangsu People's Republic of China

2. Division of Haematolgy Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology Soochow University Suzhou People's Republic of China

3. Department of Haematology Gansu Provincial People's Hospital Lanzhou People's Republic of China

Abstract

AbstractAcute promyelocytic leukemia (APL) with typically PML::RARA fusion gene caused by t (15;17) (q22; q12) was distinguished from other types of acute myeloid leukemia. In a subset of patients with APL, t (15;17) (q22;q21) and PML::RARA fusion cannot be detected. In this report, we identified the coexistence of STAT3::RARA and RARA::STAT5b fusions for the first time in a variant APL patient lacking t (15;17)(q22;q21)/PML::RARA fusion. Then, this patient was resistant to all‐trans retinoic acid combined arsenic trioxide chemotherapy. Accurate detection of RARA gene partners is crucial for variant APL, and effective therapeutic regime is urgently needed.

Publisher

Wiley

Subject

Cancer Research,Molecular Biology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/mc.23672

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