Stage I of a phase 2 study assessing the efficacy, safety, and tolerability of barasertib (AZD1152) versus low-dose cytosine arabinoside in elderly patients with acute myeloid leukemia

Author:

Kantarjian Hagop M.1,Martinelli Giovanni2,Jabbour Elias J.1,Quintás-Cardama Alfonso1,Ando Kiyoshi3,Bay Jacques-Olivier4,Wei Andrew5,Gröpper Stefanie6,Papayannidis Cristina2,Owen Kate7,Pike Laura7,Schmitt Nicola7,Stockman Paul K.7,Giagounidis Aristoteles6,

Affiliation:

1. The University of Texas MD Anderson Cancer Center; Houston Texas

2. “L. eA. Seragnoli” Institute of Hematology and Medical Oncology; University of Bologna; Bologna Italy

3. Department of Hematology and Oncology, Tokai University Hospital; Isehara Kanagawa Japan

4. Cellular Therapy and Clinic Hematology Unit for Adults; University Hospital Center; Clermont-Ferrand France

5. Department of Clinical Hematology; The Alfred Hospital, Monash University; Melbourne Australia

6. Medical Clinic II, Marien Hospital; Dusseldorf Germany

7. AstraZeneca; Alderley Park Macclesfield United Kingdom

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference30 articles.

1. Acute myeloid leukemia;Lowenberg;N Engl J Med.,1999

2. Acute myeloid leukemia;Stone;Hematology Am Soc Hematol Educ Program.,2004

3. The treatment of elderly patients with acute myeloid leukemia;Krug;Dtsch Arztebl Int.,2011

4. Validity and reliability of the FACT-G scale for use in the older person with cancer;Overcash;Am J Clin Oncol.,2001

5. Intensive chemotherapy does not benefit most older patients (age 70 years or older) with acute myeloid leukemia;Kantarjian;Blood.,2010

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