Association Between Hyperuricemia and Ultrasound‐Detected Hand Synovitis

Author:

Jiang Ting1ORCID,Weng Qianlin2ORCID,Zhang Yuqing3ORCID,Zhang Weiya4ORCID,Doherty Michael4ORCID,Sarmanova Aliya5,Yang Zidan2,Yang Tuo1ORCID,Li Jiatian2,Liu Ke2,Wang Yuqing2,Obotiba Abasiama D.6,Zeng Chao2,Lei Guanghua2ORCID,Wei Jie7ORCID

Affiliation:

1. Xiangya Hospital, Central South University, Changsha, China, the University of Nottingham, and Pain Centre Versus Arthritis UK Nottingtham United Kingdom

2. Xiangya Hospital, Central South University Changsha China

3. Massachusetts General Hospital, Harvard Medical School Boston

4. University of Nottingham and Pain Centre Versus Arthritis UK Nottingham United Kingdom

5. University of Bristol Bristol United Kingdom

6. University of Exeter Exeter United Kingdom

7. Xiangya Hospital, Central South University, and Xiangya School of Public Health, Central South University Changsha China

Abstract

ObjectiveAlthough hand synovitis is prevalent in the older population, the etiology remains unclear. Hyperuricemia, a modifiable metabolic disorder, may serve as an underlying mechanism of hand synovitis, but little is known about their relationship. We assessed the association between hyperuricemia and hand synovitis in a large population‐based sample.MethodsWe performed a cross‐sectional study in Longshan County, Hunan Province, China. Hyperuricemia was defined as a serum urate level >420 μmol/L in men and >360 μmol/L in women. Ultrasound examinations were performed on both hands of 4,080 participants, and both gray‐scale synovitis and the Power Doppler signal (PDS) were assessed using semiquantitative scores (grades 0–3). We evaluated the association of hyperuricemia with hand gray‐scale synovitis (grade ≥2) and PDS (grade ≥1), respectively, adjusting for age, sex, and body mass index.ResultsAll required assessments for analysis were available for 3,286 participants. The prevalence of hand gray‐scale synovitis was higher among participants with hyperuricemia (30.0%) than those with normouricemia (23.3%), with an adjusted odds ratio (aOR) of 1.28 (95% confidence interval [CI] 1.00–1.62). Participants with hyperuricemia also had a higher prevalence of PDS (aOR 2.36; 95% CI 1.15–4.81). Furthermore, hyperuricemia positively associated, both at the hand and joint levels, with the presence of gray‐scale synovitis (aOR 1.27; 95% CI 1.00–1.60 and adjusted prevalence ratio [aPR] 1.26; 95% CI 1.10–1.44, respectively) and PDS (aOR 2.35; 95% CI 1.15–4.79 and aPR 2.34; 95% CI 1.28–4.30, respectively).ConclusionThis population‐based study provides more evidence for a positive association between hyperuricemia and prevalent hand synovitis.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hunan Province

Fundamental Research Funds for the Central Universities of Central South University

Publisher

Wiley

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Hyperuricemia and its related diseases: mechanisms and advances in therapy;Signal Transduction and Targeted Therapy;2024-08-28

2. Ultrasound Features in Gout: An Overview;Medical Sciences;2024-07-31

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