Five Distinct Human Cytochromes Mediate Amitriptyline N-DemethylationIn Vitro: Dominance of CYP 2C19 and 3A4-Reference-Cited by-同舟云学术

Five Distinct Human Cytochromes Mediate Amitriptyline N-DemethylationIn Vitro: Dominance of CYP 2C19 and 3A4

Published:1998-02 Issue:2 Volume:38 Page:112-121
ISSN:0091-2700
Container-title:The Journal of Clinical Pharmacology
language:en
Short-container-title:

Author:

Venkatakrishnan Karthik,Greenblatt David J.,von Moltke Lisa L.,Schmider Jürgen,Harmatz Jerold S.,Shader Richard I.

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference24 articles.

1. Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA expressed human cytochrome P-450 isozymes;Olesen;Drug Metab Dispos,1997

2. The role of metabolites of antidepressants in the treatment of depression;Rudorfer;CNS Drugs,1997

3. Nortriptyline and debrisoquine hydroxylations in Ghanaian and Swedish subjects;Woolhouse;Clin Pharmacol Ther,1984

4. Amitriptyline pharmacokinetics and clinical response. II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin;Baumann;Int Clin Psychopharmacol,1986

5. Amitriptyline metabolism: association with debrisoquine hydroxylation in nonsmokers;Mellström;Clin Pharmacol Ther,1986

Cited by 142 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Non-additivity of the functional properties of individual P450 species and its manifestation in the effects of alcohol consumption on the metabolism of ketamine and amitriptyline;2024-06-15

2. Enhancing the Properties of Natural Products and Other Drugs: Deuterium: A Novel Approach;Journal of Natural Remedies;2024-03-01

3. Rates of Divergent Pharmacogenes in a Psychiatric Cohort of Inpatients with Depression—Arguments for Preemptive Testing;Journal of Xenobiotics;2022-10-28

4. Zentrales Nervensystem;Arzneimitteltherapie in der Palliativmedizin;2022

5. Role of serum amitriptyline concentration and CYP2C19 polymorphism in predicting the response to low-dose amitriptyline in irritable bowel syndrome;Digestive and Liver Disease;2021-11