Treating cachexia using soluble ACVR2B improves survival, alters mTOR localization, and attenuates liver and spleen responses

Author:

Nissinen Tuuli A.1ORCID,Hentilä Jaakko1,Penna Fabio2,Lampinen Anita1,Lautaoja Juulia H.1,Fachada Vasco1,Holopainen Tanja3,Ritvos Olli4,Kivelä Riikka3,Hulmi Juha J.14ORCID

Affiliation:

1. Neuromuscular Research Center, Biology of Physical Activity, Faculty of Sport and Health Sciences; University of Jyväskylä; Rautpohjankatu 8 Jyväskylä 40014 Finland

2. Department of Clinical and Biological Sciences; University of Turin; Corso Raffaello Turin 10125 Italy

3. Translational Cancer Biology Program, Research Programs Unit, Faculty of Medicine; University of Helsinki, and Wihuri Research Institute; Haartmaninkatu 8 Helsinki 00290 Finland

4. Department of Physiology, Faculty of Medicine; University of Helsinki; Haartmaninkatu 8 Helsinki 00290 Finland

Funder

Jenny ja Antti Wihurin Rahasto

Syöpäjärjestöt

Academy of Finland

Publisher

Wiley

Subject

Physiology (medical),Orthopedics and Sports Medicine

Reference68 articles.

1. Understanding the mechanisms and treatment options in cancer cachexia;Fearon;Nat Rev Clin Oncol,2013

2. Computed tomography-defined muscle and fat wasting are associated with cancer clinical outcomes;Kazemi-Bajestani;Semin Cell Dev Biol,2015

3. The underappreciated role of muscle in health and disease;Wolfe;Am J Clin Nutr,2006

4. Treating cancer cachexia to treat cancer;Lee;Skelet Muscle,2011

5. Is cancer cachexia attributed to impairments in basal or postprandial muscle protein metabolism?;Horstman;Forum Nutr,2016

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