Introducing the ‘Drucebo’ effect in statin therapy: a systematic review of studies comparing reported rates of statin-associated muscle symptoms, under blinded and open-label conditions

Author:

Penson Peter E.1,Mancini G. B. John2,Toth Peter P.3,Martin Seth S.3,Watts Gerald F.4,Sahebkar Amirhossein567,Mikhailidis Dimitri P.8,Banach Maciej91011ORCID,

Affiliation:

1. School of Pharmacy and Biomolecular Sciences; Liverpool John Moores University; Liverpool UK

2. Division of Cardiology, Department of Medicine; University of British Columbia; Vancouver BC Canada

3. Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Division of Cardiology, Department of Medicine; Johns Hopkins University; Baltimore MD USA

4. Lipid Disorders Clinic, Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology; The University of Western Australia; Perth WA Australia

5. Biotechnology Research Center, Pharmaceutical Technology Institute; Mashhad University of Medical Sciences; Mashhad Iran

6. Neurogenic Inflammation Research Center; Mashhad University of Medical Sciences; Mashhad Iran

7. School of Pharmacy; Mashhad University of Medical Sciences; Mashhad Iran

8. Department of Clinical Biochemistry, Royal Free Hospital Campus; University College London; London UK

9. Department of Hypertension, Chair of Nephrology and Hypertension; Medical University of Lodz; Lodz Poland

10. Polish Mother's Memorial Hospital Research Institute (PMMHRI); Lodz Poland

11. Cardiovascular Research Centre; University of Zielona Gora; Zielona Gora Poland

Publisher

Wiley

Subject

Physiology (medical),Orthopedics and Sports Medicine

Reference40 articles.

1. The nocebo reaction;Kennedy;Med World,1961

2. The nocebo effect in the context of statin intolerance;Tobert;J Clin Lipidol,2016

3. Therapeutic role of placebo: evolution of a new paradigm in understanding research and clinical practice;Manchikanti;Pain Physician,2017

4. Interpretation of the evidence for the efficacy and safety of statin therapy;Collins;Lancet,2016

5. Statin-associated side effects;Thompson;J Am Coll Cardiol,2016

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