A simple and efficient automated cGMP-compliant radiosynthesis of [11 C]metomidate using solid phase extraction cartridge purification

Author:

Kovac Mitja1ORCID,Miklovicz Tunde1,Li Lei1,Russell Joseph1,Canales Candela Roberto1,Aigbirhio Franklin1,Boros Istvan1

Affiliation:

1. Wolfson Brain Imaging Centre, Department of Clinical Neurosciences; University of Cambridge, Addenbrooke's Hospital; Cambridge CB2 0QQ UK

Funder

Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom

Medical Research Council

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Radiology, Nuclear Medicine and imaging,Biochemistry,Analytical Chemistry

Reference15 articles.

1. Increased diagnosis of primary Aldosteronism, including surgically correctable forms, in centers from five continents;Mulatero;J Clin Endocrinol Metab,2004

2. In vitro and in vivo primate evaluation of Carbon-11-etomidate and Carbon-11-Metomidate as potential tracers for PET imaging of the adrenal cortex and its tumors;Bergström;J Nucl Med,1998

3. [11C]Metomidate positron emission tomography of adrenocortical tumors in correlation with histopathological findings;Hennings;J Clin Endocrinol Metab,2006

4. PET imaging of adrenal cortical tumors with the 11beta-hydroxylase tracer 11C-metomidate;Bergström;J Nucl Med,2000

5. 11C-metomidate PET imaging of adrenocortical cancer;Khan;Eur J Nucl Med,2003

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