Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models

Author:

Holenarsipur Vinay K.1,Gaud Nilesh1,Sinha Jaydeep1,Sivaprasad Sankara1,Bhutani Priyadeep1,Subramanian Murali1,Singh Sheelendra Pratap2,Arla Rambabu1,Paruchury Sundeep1,Sharma Tarun3,Marathe Punit4,Mandlekar Sandhya15

Affiliation:

1. Pharmaceutical Candidate Optimization, Biocon Bristol-Myers Squibb R&D Centre; Syngene International Ltd; Biocon Park, Bommasandra IV Phase Bangalore 560099 India

2. Analytical Chemistry; CSIR-IITR; Lucknow 226001 India

3. Sai Life Sciences Ltd; Plot No. 2, Chrysalis Enclave, TCG International; Biotech Park Pune 411057 India

4. Pharmaceutical Candidate Optimization, Metabolism and Pharmacokinetics; Bristol-Myers Squibb; Pennington NJ 08534 USA

5. Pharmaceutical Candidate Optimization, Bristol-Myers Squibb India Pvt Ltd; Biocon Park, Bommasandra IV Phase Bangalore 560099 India

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

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