Pharmacokinetic and Pharmacodynamic Analysis of Subcutaneous Tocilizumab in Patients With Rheumatoid Arthritis From 2 Randomized, Controlled Trials: SUMMACTA and BREVACTA-Reference-Cited by-同舟云学术

Pharmacokinetic and Pharmacodynamic Analysis of Subcutaneous Tocilizumab in Patients With Rheumatoid Arthritis From 2 Randomized, Controlled Trials: SUMMACTA and BREVACTA

Published:2016-11-17 Issue:4 Volume:57 Page:459-468
ISSN:0091-2700
Container-title:The Journal of Clinical Pharmacology
language:en
Short-container-title:The Journal of Clinical Pharmacology

Author:

Abdallah Hisham¹,Hsu Joy C.¹,Lu Peng¹,Fettner Scott¹,Zhang Xiaoping¹,Douglass Wendy²,Bao Min³,Rowell Lucy²,Burmester Gerd R.⁴,Kivitz Alan⁵

Affiliation:

1. Roche Innovation Center; New York NY USA

2. Roche; Welwyn Garden City London UK

3. Genentech, Inc; South San Francisco CA USA

4. Charité-Universitätsmedizin Berlin; Free University and Humboldt University of Berlin; Berlin Germany

5. Altoona Center for Clinical Research; Duncansville PA USA

Funder

F Hoffmann-La Roche Ltd

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference21 articles.

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3. The comparative efficacy and safety of biologics for the treatment of rheumatoid arthritis: a systematic review and metaanalysis;Gartlehner;J Rheumatol,2006

4. Biologics-based therapy for the treatment of rheumatoid arthritis;Scott;Clin Pharmacol Ther,2012

5. Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family;Mihara;Int Immunopharmacol,2005

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