A case for the use of chemotherapy in hereditary mitochondrial optic neuropathies: Successful administration of cisplatin/etoposide in a male patient with testicular seminoma and Leber's hereditary optic neuropathy-Reference-Cited by-同舟云学术

A case for the use of chemotherapy in hereditary mitochondrial optic neuropathies: Successful administration of cisplatin/etoposide in a male patient with testicular seminoma and Leber's hereditary optic neuropathy

Published:2024-07 Issue:7 Volume:12 Page:
ISSN:2050-0904
Container-title:Clinical Case Reports
language:en
Short-container-title:Clinical Case Reports

Author:

Vrisakis Jean‐Luc¹^ORCID,Fraser Clare L.²³,Shahnam Adel⁴,Nindra Udit⁵,Grimison Peter⁶⁷

Affiliation:

1. Department of Medicine Royal Prince Alfred Hospital Sydney New South Wales Australia

2. Department of Medicine and Health, Save Sight Institute University of Sydney Sydney New South Wales Australia

3. Department of Ophthalmology Sydney and Sydney Eye Hospital Sydney New South Wales Australia

4. Peter MacCallum Cancer Centre Melbourne Victoria Australia

5. Cancer Therapy Centre Liverpool Hospital Sydney New South Wales Australia

6. Department of Medical Oncology Chris O'Brien Lifehouse Sydney New South Wales Australia

7. Department of Medicine and Health, Sydney Medical School University of Sydney Sydney New South Wales Australia

Abstract

Key Clinical MessageWe report on the successful use of chemotherapy for treatment of stage 2B testicular seminoma in a carrier of the Leber's hereditary optic neuropathy 11778 mitochondrial mutation. Neurotoxic chemotherapy may not prompt disease conversion.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ccr3.9045

Reference21 articles.

1. Emerging model systems and treatment approaches for Leber's hereditary optic neuropathy: Challenges and opportunities

2. Current and Emerging Treatment Modalities for Leber’s Hereditary Optic Neuropathy: A Review of the Literature

3. Real-World Clinical Experience With Idebenone in the Treatment of Leber Hereditary Optic Neuropathy

4. Understanding the molecular basis and pathogenesis of hereditary optic neuropathies: towards improved diagnosis and management

5. Successful chemotherapy in a male patient with malignant lymphoma and Leber's hereditary optic neuropathy (LHON)