Affiliation:
1. Tianjin Key Laboratory of Brain Science and Neural Engineering Academy of Medical Engineering and Translational Medicine, Tianjin University Tianjin China
2. Department of Pathology Tianjin Third Central Hospital, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Tianjin China
3. Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences Tianjin University Tianjin China
Abstract
AbstractHeterogeneous cells are the main feature of tumors with unique genetic and phenotypic characteristics, which can stimulate differentially the progression, metastasis, and drug resistance. Importantly, heterogeneity is pervasive in human malignant tumors, and identification of the degree of tumor heterogeneity in individual tumors and progression is a critical task for tumor treatment. However, current medical tests cannot meet these needs; in particular, the need for noninvasive visualization of single‐cell heterogeneity. Near‐infrared II (NIR‐II, 1000–1700 nm) imaging exhibits an exciting prospect for non‐invasive monitoring due to the high temporal‐spatial resolution. More importantly, NIR‐II imaging displays more extended tissue penetration depths and reduced tissue backgrounds because of the significantly lower photon scattering and tissue autofluorescence than traditional the near‐infrared I (NIR‐I) imaging. In this review, we summarize systematically the advances made in NIR‐II in tumor imaging, especially in the detection of tumor heterogeneity and progression as well as in tumor treatment. As a non‐invasive visual inspection modality, NIR‐II imaging shows promising prospects for understanding the differences in tumor heterogeneity and progression and is envisioned to have the potential to be used clinically.
Funder
National Natural Science Foundation of China
National Institutes of Health
Cited by
33 articles.
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