Buddlejasaponin IV Induces Cell Cycle Arrest at G2/M Phase and Apoptosis in Immortalized Human Oral Keratinocytes

Author:

Hwang Young Sun1,Chung Won-Yoon12,Kim Jin13,Park Hee-Juhn4,Kim Eun-Cheol5,Park Kwang-Kyun12

Affiliation:

1. Oral Cancer Research Institute; Yonsei University College of Dentistry; Korea

2. Department of Oral Biology; Yonsei University College of Dentistry; Korea

3. Department of Oral Pathology; Yonsei University College of Dentistry; Korea

4. Department of Pharmaceutical Engineering; Sangji University; Wonju Korea

5. Department of Oral and Maxillofacial Pathology; Wonkwang University; Iksan South Korea

Funder

Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea

Publisher

Wiley

Subject

Pharmacology

Reference30 articles.

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2. High incidence of p53 alterations (mutation, deletion, overexpression) in head and neck primary tumors and metastases; absence of correlation with clinical outcome. Frequent protein overexpression in normal epithelium and in early non-invasive lesions;Ahomadegbe;Oncogene,1995

3. Human papillomavirus: its identity and controversial role in oral oncogenesis, premalignant and malignant lesions (review);Campisi;Int J Oncol,2007

4. Regulation of cell death protease caspase-9 by phosphorylation;Cardone;Science,1998

5. Prognostic significance of p53 expression in oral squamous cell carcinoma without neck node metastases;Carlos de Vincente;Head Neck,2004

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