A comprehensive gas chromatography electron ionization high resolution mass spectrometry study of a new steroidal selective androgen receptor modulator (SARM) compound S42-Reference-Cited by-同舟云学术

A comprehensive gas chromatography electron ionization high resolution mass spectrometry study of a new steroidal selective androgen receptor modulator (SARM) compound S42

Published:2024-08 Issue:8 Volume:59 Page:
ISSN:1076-5174
Container-title:Journal of Mass Spectrometry
language:en
Short-container-title:J Mass Spectrom

Author:

Wen Hui‐Chung¹,Wilczek Tobias¹,Neudörfl Jörg‐M.¹,Wagener Felicitas²,Piper Thomas²,Thevis Mario²,Schäfer Mathias¹^ORCID

Affiliation:

1. Department of Chemistry, Institute of Organic Chemistry University of Cologne Cologne Germany

2. Center for Preventive Doping Research/Institute of Biochemistry German Sport University Cologne Cologne Germany

Abstract

AbstractThe synthetic 20‐keto‐steroid S42 (1) demonstrated selective androgen receptor modulator (SARM) properties in preclinical studies and, consequently, received growing attention also in the context of sports drug testing programs. Fundamental understanding of the behavior of S42 (1) and of relevant derivatives in gas chromatography‐electron ionization MS experiments at high resolution (GC‐EI‐HRMS) is indispensable to develop a reliable qualitative and quantitative doping control method for S42 (1) and its metabolites in body fluid matrices. We present important fundamental mechanistic data on the EI fragmentation behavior of S42 (1) and of silyl ether derivatives as well as of stable isotope‐labelled reference material.

Publisher

Wiley

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