Acute and chronic kidney injury during therapy for pediatric acute leukemia: A report from the Leukemia Electronic Abstraction of Records Network (LEARN)-Reference-Cited by-同舟云学术

Acute and chronic kidney injury during therapy for pediatric acute leukemia: A report from the Leukemia Electronic Abstraction of Records Network (LEARN)

Published:2023-09-30 Issue:12 Volume:70 Page:
ISSN:1545-5009
Container-title:Pediatric Blood & Cancer
language:en
Short-container-title:Pediatric Blood & Cancer

Author:

Hsiao Wendy¹²^ORCID,Li Yimei³⁴,Getz Kelly³⁴⁵,Cao Lusha⁶^ORCID,Krause Edward⁶,Ramos Mark⁶,Lee Judy⁷,Gramatges Maria Monica⁸⁹,Rabin Karen R.⁸⁹,Scheurer Michael E.⁸⁹,Aplenc Richard³⁵,Denburg Michelle²⁴⁵,Miller Tamara P.⁷¹⁰^ORCID

Affiliation:

1. Division of Nephrology Children's Hospital Los Angeles Los Angeles California USA

2. Division of Nephrology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

3. Division of Oncology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

4. Department of Biostatistics Epidemiology, and Informatics Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

5. Department of Pediatrics Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

6. Department of Biomedical and Health Informatics Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

7. Aflac Cancer & Blood Disorders Center Children's Healthcare of Atlanta Atlanta Georgia USA

8. Cancer and Hematology Center Texas Children's Hospital Houston Texas USA

9. Division of Hematology‐Oncology Department of Pediatrics Baylor College of Medicine Houston Texas USA

10. Department of Pediatrics Emory University School of Medicine Atlanta Georgia USA

Abstract

AbstractChildren with acute leukemia are at increased risk of kidney injury. Using electronic health record data from three centers between 2010 and 2018, this study retrospectively described acute kidney injury (AKI) and chronic kidney disease (CKD) prevalence in children with acute lymphoblastic or myeloid leukemia (ALL, AML) using Common Terminology Criteria for Adverse Events (CTCAE) and Kidney Disease Improving Global Outcomes (KDIGO) definitions. AKI during therapy was 25% (ALL) and 32% (AML) using CTCAE, versus 84% (ALL) and 74% (AML) using KDIGO. CKD prevalence was low and Grade 1/Stage 2. Further investigation is needed to optimally define kidney injury in acute leukemia.

Funder

National Cancer Institute

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/pbc.30696

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