Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors

Author:

Flores‐Bellver Miguel1ORCID,Mighty Jason23,Aparicio‐Domingo Silvia1,Li Kang V.1,Shi Cui23,Zhou Jing2,Cobb Hannah1,McGrath Patrick4,Michelis German5,Lenhart Patricia1,Bilousova Ganna467,Heissel Søren8,Rudy Michael J.9,Coughlan Christina10,Goodspeed Andrew E.1112,Becerra S. Patricia5,Redenti Stephen2313,Canto‐Soler M. Valeria16

Affiliation:

1. CellSight Ocular Stem Cell and Regeneration Program Department of Ophthalmology Sue Anschutz‐Rodgers Eye Center University of Colorado, School of Medicine Aurora Colorado USA

2. Lehman College Bronx New York USA

3. Biology Doctoral Program The Graduate School and University Center City University of New York New York New York USA

4. Department of Dermatology University of Colorado School of Medicine Aurora Colorado USA

5. Section of Protein Structure and Function NEI NIH Bethesda Maryland USA

6. Charles C. Gates Center for Regenerative Medicine University of Colorado School of Medicine Aurora Colorado USA

7. Linda Crnic Institute for Down Syndrome University of Colorado School of Medicine Aurora Colorado USA

8. Proteomics Resource Center The Rockefeller University New York New York USA

9. Department of Neurology University of Colorado School of Medicine Aurora Colorado USA

10. University of Colorado Alzheimer's and Cognition Center Department of Neurology Linda Crnic Institute for Down Syndrome University of Colorado Anschutz Medical Campus Aurora Colorado USA

11. Department of Pharmacology University of Colorado Anschutz Medical Campus Aurora Colorado USA

12. University of Colorado Cancer Center University of Colorado Anschutz Medical Campus Aurora Colorado USA

13. Biochemistry Doctoral Program The Graduate School City University of New York New York New York USA

Funder

National Eye Institute

National Institute of General Medical Sciences

Maryland Stem Cell Research Fund

Research to Prevent Blindness

BrightFocus Foundation

Publisher

Wiley

Subject

Cell Biology,Histology

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