Computational Design and Discovery of Conformationally Flexible Inhibitors of Acetohydroxyacid Synthase to Overcome Drug Resistance Associated with the W586L Mutation-Reference-Cited by-同舟云学术

Computational Design and Discovery of Conformationally Flexible Inhibitors of Acetohydroxyacid Synthase to Overcome Drug Resistance Associated with the W586L Mutation

Published:2008-08-18 Issue:8 Volume:3 Page:1203-1206
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Ji Feng-Qin,Niu Cong-Wei,Chen Chao-Nan,Chen Qiong,Yang Guang-Fu,Xi Zhen,Zhan Chang-Guo

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference32 articles.

1. Structure of the Regulatory Subunit of Acetohydroxyacid Synthase Isozyme III from Escherichia coli

2. Characterization of acetohydroxyacid synthase fromMycobacterium tuberculosisand the identification of its new inhibitor from the screening of a chemical library

3. Rational Design Based on Bioactive Conformation Analysis of Pyrimidinylbenzoates as Acetohydroxyacid Synthase Inhibitors by Integrating Molecular Docking, CoMFA, CoMSIA, and DFT Calculations

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