Discovery of a Potent, CNS-Penetrant Orexin Receptor Antagonist Based on anN,N-Disubstituted-1,4-diazepane Scaffold that Promotes Sleep in Rats

Author:

Whitman David B.,Cox Christopher D.,Breslin Michael J.,Brashear Karen M.,Schreier John D.,Bogusky Michael J.,Bednar Rodney A.,Lemaire Wei,Bruno Joseph G.,Hartman George D.,Reiss Duane R.,Harrell C. Meacham,Kraus Richard L.,Li Yuxing,Garson Susan L.,Doran Scott M.,Prueksaritanont Thomayant,Li Chunze,Winrow Christopher J.,Koblan Kenneth S.,Renger John J.,Coleman Paul J.

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference21 articles.

1. For a compilation of the extensive investigations carried out to identify the orexin system and define its physiological roles, see:

2. Hypocretins: Integrators of Physiological Functions, (Eds.: L. de Lecea, J. G. Sutcliffe), Springer, New York, 2005.

3. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

4. Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior

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