Sleep interventions in pediatric oncology: A systematic review of the evidence

Author:

Daniel Lauren C.1ORCID,Catarozoli Corinne2,Crabtree Valerie McLaughlin3ORCID,Bridgeman Matthew4,van Litsenburg Raphaele5,Irestorm Elin6ORCID

Affiliation:

1. Rutgers University Camden Camden New Jersey USA

2. Weill Cornell Medicine New York New York USA

3. St. Jude Children's Research Hospital Memphis Tennessee USA

4. Rutgers University New Brunswick New Jersey USA

5. Princess Máxima Center for Pediatric Oncology Utrecht Netherlands

6. Faculty of Medicine, Department of Paediatrics Lund University Lund Sweden

Abstract

AbstractSleep concerns are common during pediatric cancer treatment and can last into survivorship. The current systematic review sought to identify intervention studies that addressed sleep as a primary or secondary outcome during pediatric cancer treatment up to 5 years after completing treatment. Quality assessment was rated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. The review identified 16 studies with a total of 943 participants that tested a wide range of interventions including psycho‐educational, stress management techniques, medications, and physical activity. Most studies included tested interventions in small samples. None of the included studies had a high risk of bias for all domains, but all included studies had a high risk of bias for at least two risk domains. Several feasible pilot studies were identified that warrant further research to test efficacy. Implications for future research and clinical practice to manage sleep concerns are discussed.

Publisher

Wiley

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