Caffeine and cortical excitability, as measured with paired‐pulse transcranial magnetic stimulation

Author:

Strunge Kristine1,Bostock Hugh2,Howells James3,Cengiz Bülent4ORCID,Samusyte Gintaute56,Koltzenburg Martin7,Tankisi Hatice18ORCID

Affiliation:

1. Department of Clinical Neurophysiology Aarhus University Hospital Aarhus Denmark

2. Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology London UK

3. Central Clinical School, Faculty of Medicine and Health University of Sydney Sydney Australia

4. Department of Neurology Gazi University Faculty of Medicine Ankara Turkey

5. Department of Neurology Hospital of Lithuanian University of Health Sciences Kauno Klinikos Kaunas Lithuania

6. Department of Neurology Medical Academy, Lithuanian University of Health Sciences Kaunas Lithuania

7. Department of Clinical Neurophysiology National Hospital for Neurology and Neurosurgery London UK

8. Department of Clinical Medicine Aarhus University Aarhus Denmark

Abstract

AbstractIntroduction/AimsThe transcranial magnetic stimulation tests of short‐interval intracortical inhibition (SICI) by both conventional amplitude measurements (A‐SICI) and threshold‐tracking (T‐SICI) are important methods to investigate intracortical inhibitory circuits, and T‐SICI has been proposed to aid the diagnosis of amyotrophic lateral sclerosis. Beverages containing caffeine are widely consumed, and caffeine has been reported to affect cortical excitability. The aim of this study was to determine whether these SICI tests are affected by caffeine.MethodsTwenty‐four healthy subjects (13 females, 11 males, aged from 19 to 31, mean: 26.2 ± 2.4 years) were studied in a single fixed‐dose randomized double‐blind placebo‐controlled cross‐over trial of 200 mg caffeine or placebo ingested as chewing gum. A‐SICI and T‐SICI, using parallel tracking (T‐SICIp), were performed before and after chewing gum.ResultsThere was no significant change in SICI parameters after placebo in A‐SICI (p > .10) or T‐SICIp (p > .30), and no significant effect of caffeine was found on A‐SICI (p > .10) or T‐SICIp (p > .50) for any of the interstimulus intervals.DiscussionThere is no need for caffeine abstention before measurements of SICI by either the T‐SICI or A‐SICI measurements.

Funder

Lundbeck Foundation

Grosserer L. F. Foghts Fond

Aase og Ejnar Danielsens Fond

Dagmar Marshalls Fond

Publisher

Wiley

Subject

Physiology (medical),Cellular and Molecular Neuroscience,Neurology (clinical),Physiology

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