Physiologically Based Pharmacokinetic Modelling to Investigate the Impact of the Cytokine Storm on CYP3A Drug Pharmacokinetics in COVID‐19 Patients-Reference-Cited by-同舟云学术

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Physiologically Based Pharmacokinetic Modelling to Investigate the Impact of the Cytokine Storm on CYP3A Drug Pharmacokinetics in COVID‐19 Patients

Published:2021-09-22 Issue:3 Volume:111 Page:579-584
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin Pharma and Therapeutics

Author:

Stader Felix¹²,Battegay Manuel¹²,Sendi Parham¹²³,Marzolini Catia¹²⁴

Affiliation:

1. Departments of Medicine and Clinical Research University Hospital Basel Basel Switzerland

2. University of Basel Basel Switzerland

3. Institute for Infectious Diseases University of Bern Bern Switzerland

4. Department of Molecular and Clinical Pharmacology Institute of Translational Medicine University of Liverpool Liverpool UK

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.2402

Reference29 articles.

1. Effects of Interleukin-6 (IL-6) and an Anti-IL-6 Monoclonal Antibody on Drug-Metabolizing Enzymes in Human Hepatocyte Culture

2. Impact of Infectious and Inflammatory Disease on Cytochrome P450–Mediated Drug Metabolism and Pharmacokinetics

3. Impact of Acute Inflammation on Cytochromes P450 Activity Assessed by the Geneva Cocktail

4. Disease–Drug–Drug Interaction Involving Tocilizumab and Simvastatin in Patients With Rheumatoid Arthritis

5. Disease–Drug Interaction of Sarilumab and Simvastatin in Patients with Rheumatoid Arthritis

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5. Evaluation of the potential impact on pharmacokinetics of various cytochrome P450 substrates of increasing IL‐6 levels following administration of the T‐cell bispecific engager glofitamab;CPT: Pharmacometrics & Systems Pharmacology;2023-12-14

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