Affiliation:
1. Department of Entomology and MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection China Agricultural University Beijing China
2. College of Life Science, Institute of Life Science and Green Development Hebei University Baoding China
Abstract
AbstractBackgroundFeeding is the basis of animal survival and reproduction. In insects, the neuropeptide F (NPF), a homologous polypeptide of NPY in vertebrates, plays an important role in regulation of feeding behavior. However, relatively little has been known about the molecular mechanism of feeding.ResultsIn this study, we show that the cholinergic pathway is very important in signaling transmission of NPF feeding regulation in Ostrinia furnacalis larvae, in which the choline acetyltransferase (ChAT), the vesicular acetylcholine transporter (vAChT) in presynaptic membrane and the nicotinic acetylcholine receptor (nAChR) in postsynaptic membrane are positively regulated by NPF, while the ace1 and ace2 encoding the acetylcholinesterase (AChE) are negatively regulated by NPF, leading to a balance of acetylcholine (ACh)‐the excitatory transmitter. More, the cholinergic pathway further transmits signaling to the downstream pathways of the phosphoInositide‐3 kinase (PI3K) and the cAMP responsive element binding protein (CREB), respectively.ConclusionThe cholinergic transmission, positively regulated by NPF, is involved in feeding of O. furnacalis larvae via downstream PI3K and the CREB pathways, respectively. The deexcitation of cell cholinergic pathway or inhibition of PI3K and CREB lead to decreases of larval feeding amount. © 2023 Society of Chemical Industry.
Funder
National Natural Science Foundation of China
Subject
Insect Science,Agronomy and Crop Science,General Medicine
Cited by
1 articles.
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