A rapid and sensitive determination of hypoxic radiosensitizer agent nimorazole in rat plasma by LC-MS/MS and its application to a pharmacokinetic study

Author:

Das Soumyajit1,Dubey Ramkumar1,Roychowdhury Subhradip1,Ghosh Manik1ORCID,Sinha Barij Nayan1,Kumar Pradhan Kishanta1,Bal Trishna1,Muthukrishnan Venkateswari2,Seijas Julio A.3,Pujarid Abhijit4

Affiliation:

1. Department of Pharmaceutical Sciences and Technology; Birla Institute of Technology, Mesra; Ranchi India

2. CERTARA, Translational Science Solutions; USA

3. Departamento de Química Orgánica; Universidad De Santiago De Compostela, Facultad de Ciencias-Campus de Lugo; Lugo Spain

4. Centre for Food Testing; Bharati Vidyapeeth Deemed University; Pune India

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference26 articles.

1. Radiation, hypoxia and genetic stimulation: implications for future therapies;Adams;Radiotherapy and Oncology,1998

2. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma;Brizel;Cancer Research,1996

3. Difference in pO2 peaks of a murine fibrosarcoma between carbon-ion and Xray irradiation;Fukawa;Journal of Radiation Research,2004

4. The mechanism of action of nitro-heterocyclic antimicrobial drugs. Primary target of l-methyl-2-nitro-5-vinylimidazole is DNA;Goldstein;Journal of General Microbiology,1977

5. Treatment of head and neck cancer with CHART and nimorazole: phase II study;Henk;Radiotherapy and Oncology,2003

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