Calmodulin Binding to Death Receptor 5-mediated Death-Inducing Signaling Complex in Breast Cancer Cells

Author:

Fancy Romone M.1,Kim Harrison2,Zhou Tong3,Zinn Kurt R.2,Buchsbaum Donald J.4,Song Yuhua1

Affiliation:

1. Department of Biomedical Engineering; The University of Alabama at Birmingham; Birmingham 35294 Alabama

2. Department of Radiology; The University of Alabama at Birmingham; Birmingham 35294 Alabama

3. Department of Medicine; The University of Alabama at Birmingham; Birmingham 35294 Alabama

4. Department of Radiation Oncology; The University of Alabama at Birmingham; Birmingham 35294 Alabama

Funder

National Institutes of Health

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference47 articles.

1. Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells;Amm;Mol Cancer Res,2011

2. Safety and antitumor activity of recombinant soluble Apo2 ligand;Ashkenazi;J Clin Invest,1999

3. Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding;Bin;J Biol Chem,2007

4. Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in combination with chemotherapy and/or radiation therapy in a human breast cancer model;Buchsbaum;Clin Cancer Res,2003

5. Cohen P Klee CB 1988

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