Burden of cancers attributable to high fasting plasma glucose in the Middle East and North Africa region, 1990–2019

Author:

Tondro Anamag Farhad1,Noori Maryam23,Nejadghaderi Seyed Aria45ORCID,Sullman Mark J. M.67,Grieger Jessica A.89,Kolahi Ali‐Asghar10ORCID,Safiri Saeid111ORCID

Affiliation:

1. Social Determinants of Health Research Center, Department of Community Medicine, Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran

2. Student Research Committee, School of Medicine Iran University of Medical Sciences Tehran Iran

3. Urology Research Center Tehran University of Medical Sciences Tehran Iran

4. Research Center for Integrative Medicine in Aging Aging Research Institute, Tabriz University of Medical Sciences Tabriz Iran

5. Systematic Review and Meta‐analysis Expert Group (SRMEG) Universal Scientific Education and Research Network (USERN) Tehran Iran

6. Department of Life and Health Sciences University of Nicosia Nicosia Cyprus

7. Department of Social Sciences University of Nicosia Nicosia Cyprus

8. Adelaide Medical School University of Adelaide Adelaide South Australia Australia

9. Robinson Research Institute University of Adelaide Adelaide South Australia Australia

10. Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran

11. Hematology and Oncology Research Center Tabriz University of Medical Sciences Tabriz Iran

Abstract

AbstractBackgroundThe present study reported the cancer deaths and disability‐adjusted life years (DALYs) that were attributable to high fasting plasma glucose (HFPG) in the Middle East and North Africa (MENA) region by country, age, sex, cancer type and Socio‐demographic Index (SDI), from 1990 to 2019.MethodsGlobal Burden of Disease (GBD) 2019 data were used to report the cancer‐related deaths and DALYs that were attributable to HFPG, for all MENA countries over the period 1990–2019. The results were presented as numbers, population attributable fractions (PAFs) and rates (per 100,000) with 95% uncertainty intervals.ResultsIn 2019, there were an estimated 19.8 thousand (5.5–40.2) cancer deaths attributable to HFPG in MENA, which represents 4.7% (1.3–9.3) of all cancer‐related deaths. The number of regional DALYs due to HFPG‐related cancers was 462.2 thousand (127.3–959.5), which represents 3.8% (1.1–7.6) of all cancer‐related DALYs in 2019. From 1990 to 2019, the age‐standardized DALY rate of cancers attributable to HFPG (per 100,000) grew from 56.3 (14.6–121.1) to 107.0 (29.8–220.8), which was a 90.1% (64.4–127.8) increase. In 2019, the highest age‐standardized DALY rate of cancers attributable to HFPG was in Qatar (270.4) and the lowest was in Sudan (75.3). The DALY rate of cancers attributable to HFPG increased with age, peaking for males in the 70–74 age group and for females in the 75–79 age group, and then decreased for both sexes. A broadly positive relationship was found between the national SDI and the national age‐standardized DALY rate of all cancers attributable to FPG over the measurement period.ConclusionsThe burden of HFPG‐related cancers has increased over the past three decades in MENA, and was higher than the global average in multiple age groups. Implementing a battery of preventive measures and therapeutic interventions is suggested to address the adverse effects of this modifiable risk factor.

Funder

Shahid Beheshti University of Medical Sciences

Publisher

Wiley

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology

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