Metabolomic profiling of rat urine after oral administration of the prescription antipyretic Hao Jia Xu Re Qing Granules by UPLC/Q-TOF-MS

Author:

Yu Chu-qin12,Chen Jian-ping3,Zhong Yan-mei4ORCID,Zhong Xun-long5,Tang Chun-ping1,Yang Yi12,Lin Hua-qing12

Affiliation:

1. Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems; Guangdong Pharmaceutical University; Guangzhou China

2. School of Pharmacy; Guangdong Pharmaceutical University; Guangzhou China

3. The First Hospital Affiliated to Sun Yat-sen University; Guangzhou P.R. China

4. Central Laboratory; Guangdong Pharmaceutical University; Guangzhou China

5. Department of Pharmacy; The Second Affiliated Hospital of Guangzhou Medical University; Guangzhou P.R. China

Funder

Science and Technology Plan of Guangdong Province

Joint research project of science and technology department of Guangdong province and Guangdong Academy of Chinese Medicine

Project for Innovative Young Talents in Colleges and Universities in Guangdong Province

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference20 articles.

1. Large-scale human metabolomics studies: A strategy for data (pre-) processing and validation;Bijlsma;Analytical Chemistry,2006

2. 5-Hydroxytryptamine 1A receptor activation reduces cutaneous vasoconstriction and fever associated with the acute inflammatory response in rabbits;Blessing;Neurosciences,2004

3. OPLS discriminant analysis: Combining the strengths of PLS-DA and SIMCA classification;Bylesjo;Journal of Chemometrics,2006

4. The Study of consitituents from HaoJiaXu Re Qing granules based on ultra performance liquid chromatography time-of-flight mass spectrometry (UHPLC/Q-TOF-MS);Chen;Journal of Chinese Medicinal Materials,2017

5. 5-HT2A-mu opioid receptor mechanisms in the hypothalamus mediate interleukin-1beta fever in rats;Chio;Neuroscience Letters,2005

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