Extended-release but not immediate-release and subcutaneous methylnaltrexone antagonizes the loperamide-induced delay of whole-gut transit time in healthy subjects

Author:

Kolbow Julia1,Modess Christiane1,Wegner Danilo1,Oswald Stefan1,Maritz Martina Alice2,Rey Hélène2,Weitschies Werner3,Siegmund Werner1

Affiliation:

1. Department of Clinical Pharmacology, Center of Drug Absorption and Transport; University Medicine; Greifswald Germany

2. Develco Pharma Schweiz AG; Pratteln Switzerland

3. Department of Pharmaceutical Technology and Biopharmacy, Center of Drug Absorption and Transport; University of Greifswald; Greifswald Germany

Funder

Department of Clinical Pharmacology, University Medicine Greifswald (Greifswald, Germany) from Develco Pharma Schweiz AG (Pratteln, Switzerland)

German Federal Ministry of Education and Research Grants

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference44 articles.

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2. The role of opioid receptor antagonists in the treatment of opioid-induced constipation: a review;Leppert;Adv Ther,2010

3. Incidence, prevalence, and management of opioid bowel dysfunction;Pappagallo;Am J Surg,2001

4. Management of common opioid-induced adverse effects;Swegle;Am Fam Physician,2006

5. Inhibition of gastrointestinal transit by morphine in rats results primarily from direct drug-action on gut opioid sites;Manara;J Pharmacol Exp Ther,1986

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