Metabolism and Excretion of Nirmatrelvir in Humans Using Quantitative Fluorine Nuclear Magnetic Resonance Spectroscopy: A Novel Approach for Accelerating Drug Development-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Metabolism and Excretion of Nirmatrelvir in Humans Using Quantitative Fluorine Nuclear Magnetic Resonance Spectroscopy: A Novel Approach for Accelerating Drug Development

Published:2022-06-29 Issue:6 Volume:112 Page:1201-1206
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin Pharma and Therapeutics

Author:

Singh Ravi Shankar P.¹^ORCID,Walker Gregory S.²^ORCID,Kadar Eugene P.²,Cox Loretta M.²,Eng Heather²^ORCID,Sharma Raman²,Bergman Arthur J.¹,Van Eyck Lien³,Hackman Frances⁴,Toussi Sima S.⁵,Kalgutkar Amit S.¹^ORCID,Obach R. Scott²^ORCID

Affiliation:

1. Pfizer Worldwide Research, Development & Medical Cambridge Massachusetts USA

2. Pfizer Worldwide Research, Development & Medical Groton Connecticut USA

3. Pfizer Clinical Research Unit Brussels Belgium

4. Pfizer Worldwide Research, Development and Medical Cambridge UK

5. Pfizer Clinical Development Pearl River New York USA

Funder

Pfizer

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.2683

Reference14 articles.

1. An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

2. Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19

3. Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern

4. Innovative Randomized Phase I Study and Dosing Regimen Selection to Accelerate and Inform Pivotal COVID‐19 Trial of Nirmatrelvir

5. The Importance of the Human Mass Balance Study in Regulatory Submissions

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Alpibectir: Early Qualitative and Quantitative Metabolic Profiling from a First-Time-in-Human Study by Combining¹⁹F-NMR (Nuclear Magnetic Resonance),¹H-NMR, and High-Resolution Mass Spectrometric Analyses;Drug Metabolism and Disposition;2024-05-20

2. Physiologically‐based pharmacokinetic modelling guided dose evaluations of nirmatrelvir/ritonavir in renal impairment for the management of COVID‐19;British Journal of Clinical Pharmacology;2024-04-14

3. In vivo and in vitro metabolite profiling of nirmatrelvir using LC–Q‐ToF–MS/MS along with the in silico approaches for prediction of metabolites and their toxicity;Biomedical Chromatography;2024-02-25

4. Meeting report of the 4th European biotransformation workshop;Xenobiotica;2024-01-17

5. Recommendations on the Use of Multiple Labels in Human Mass Balance Studies;Drug Metabolism and Disposition;2024-01-12

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号京ICP备18003416号-3