Cellular therapy in lymphoma

Author:

Sureda Anna1,Lugtenburg Pieternella J.2,Kersten Marie José3,Subklewe Marion45,Spanjaart Anne3,Shah Nirali N6,Kerbauy Lucila N7,Roddie Clarie8,Pennings Elise R. A.3ORCID,Mahuad Carolina9,Poon Michelle10,Hendricks Candice L1112,Kamdar Manali13,Jacobson Caron14ORCID

Affiliation:

1. Clinical Hematology Department Institut Catala d’Oncologia – Hospitalet Institut d’Investigatcions Biomediques de Bellvitge (IDIBELL) Universitat de Barcelona Barcelona Spain

2. Erasmus MC Cancer Institute University Medical Center Rotterdam Rotterdam The Netherlands

3. Department of Hematology Amsterdam Universitair Medische Centra Amsterdam The Netherlands

4. Department of Medicine III University Hospital LMU Munich Germany

5. Laboratory for Translational Cancer Immunology LMU Gene Center Munich Germany

6. Pediatric Oncology Branch Center for Cancer Research (CCR) National Cancer Institute (NCI) NIH Bethesda Maryland USA

7. Departments of Stem Cell Transplantation and Hemotherapy/Cellular Therapy Hospital Israelita Albert Einstein Sao Paolo Brazil

8. Research Department of Haematology Cancer Institute University College London London UK

9. Hematology Service Department of Internal Medicine Deutsches Hospital Buenos Aires Argentina

10. Department of Haematology‐Oncology National University Cancer Institute Singapore Singapore

11. Institute for Cellular and Molecular Medicine Department of Immunology Faculty of Health Sciences University of Pretoria Pretoria South Africa

12. SAMRC Extramural Unit for Stem Cell Research and Therapy Faculty of Health Sciences University of Pretoria Pretoria South Africa

13. University of Colorado Aurora Colorado USA

14. Department of Medical Oncology Dana‐Farber Cancer Institute Boston Massachusetts USA

Abstract

AbstractCD19‐directed chimeric antigen receptor (CAR) T‐cell therapy has had a dramatic impact on the natural history and survival of patients with high‐risk B‐cell non‐Hodgkin lymphoma. Accompanying this success has been the development of new fields of medicine and investigation into toxicity risks and mitigation therapies, mechanisms of resistance and the development of novel and next generation products and strategies in order to address relapse, and issues related to global access and health care economics. This article is a survey of each of these areas as it pertains to the rapidly evolving field of CAR T‐cell therapy, written by an International community of lymphoma experts, who also happen to be women.

Publisher

Wiley

Subject

Cancer Research,Oncology,Hematology,General Medicine

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