Immediate major dynamic changes in the T‐ and NK‐cell subset composition after cardiac transplantation

Author:

Iske Jasper12,Wiegmann Bettina34,Ius Fabio34,Chichelnitskiy Evgeny1,Ludwig Kristina1,Kühne Jenny F.1,Hitz Anna Maria1,Beushausen Kerstin1,Keil Jana1,Iordanidis Susanne1,Rojas Sebastián V.5,Sommer Wiebke6,Salman Jawad3,Haverich Axel3,Warnecke Gregor6,Falk Christine S147

Affiliation:

1. Institute of Transplant Immunology Hannover Medical School Hannover Germany

2. Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charité (DHZC) Berlin Germany

3. Department for Cardiothoracic Transplantation and Vascular Surgery Hannover Medical School Hannover Germany

4. German Center for Lung Research BREATH, Hannover Medical School Hannover Germany

5. Heart and Diabetes Center Nordrhein‐Westfalen University Hospital Ruhr‐University Bochum Bad Oeynhausen Germany

6. Department of Cardiac Surgery University Hospital Heidelberg UK‐HD Heidelberg Germany

7. German Center for Infection Research TTU‐IICH Hannover–Braunschweig site Germany

Abstract

AbstractEarly kinetics of lymphocyte subsets involved in tolerance and rejection following heart transplantation (HTx) are barely defined. Here, we aimed to delineate the early alloimmune response immediately after HTx. Therefore, blood samples from 23 heart‐transplanted patients were collected before (pre‐), immediately (T0), 24 hours (T24), and 3 weeks (3 wks) after HTx. Immunophenotyping was performed using flow cytometry. A significant increase was detected for terminally differentiated (TEMRA) CD4+ or CD8+ T cells and CD56dimCD16+ NK cells immediately after HTx linked to a decrease in naïve CD8+ and CM CD4+ T as well as CD56brightCD16 NK cells, returning to baseline levels at T24. More detailed analyses revealed increased CD69+CD25 and diminished CD69CD25CD4+ or CD8+ T‐cell proportions at T0 associated with decreasing S1PR1 expression. Passenger T and NK cells were found at low frequencies only in several patients at T0 and did not correlate with lymphocyte alterations. Collectively, these results suggest an immediate, transient shift toward memory T and NK cells following HTx. Opposite migratory properties of naïve versus memory T and NK cells occurring in the early phase after HTx could underlie these observations and may impinge on the development of allo‐specific immune responses.

Funder

Deutsche Forschungsgemeinschaft

Deutsches Zentrum für Infektionsforschung

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

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