Neuroanatomy of lymphoid organs: Lessons learned from whole‐tissue imaging studies

Author:

Cao Ying1,Chen Hongjie2,Yang Jing1345

Affiliation:

1. Center for Life Sciences Academy for Advanced Interdisciplinary Studies Peking University Beijing China

2. Peking University‐Tsinghua University‐National Institute of Biological Sciences Joint Graduate Program Academy for Advanced Interdisciplinary Studies Peking University Beijing China

3. State Key Laboratory of Membrane Biology School of Life Sciences Peking University Beijing China

4. IDG/McGovern Institute for Brain Research Peking University Beijing China

5. Shenzhen Bay Laboratory Institute of Molecular Physiology Shenzhen China

Abstract

AbstractDecades of extensive research have documented the presence of neural innervations of sensory, sympathetic, or parasympathetic origin in primary and secondary lymphoid organs. Such neural inputs can release neurotransmitters and neuropeptides to directly modulate the functions of various immune cells, which represents one of the essential aspects of the body's neuroimmune network. Notably, recent studies empowered by state‐of‐the‐art imaging techniques have comprehensively assessed neural distribution patterns in BM, thymus, spleen, and LNs of rodents and humans, helping clarify several controversies lingering in the field. In addition, it has become evident that neural innervations in lymphoid organs are not static but undergo alterations in pathophysiological contexts. This review aims to update the current information on the neuroanatomy of lymphoid organs obtained through whole‐tissue 3D imaging and genetic approaches, focusing on anatomical features that may designate the functional modulation of immune responses. Moreover, we discuss several critical questions that call for future research, which will advance our in‐depth understanding of the importance and complexity of neural control of lymphoid organs.

Funder

National Key Research and Development Program of China

China Postdoctoral Science Foundation

Natural Science Foundation of Beijing Municipality

National Natural Science Foundation of China

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

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1. Introductory Chapter: Lymphatic System Human Anatomy;Lymphatic System - From Human Anatomy to Clinical Practice;2024-02-07

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