CDK ‐mediated activation of the SCF FBXO 28 ubiquitin ligase promotes MYC ‐driven transcription and tumourigenesis and predicts poor survival in breast cancer-Reference-Cited by-同舟云学术

CDK ‐mediated activation of the SCF FBXO 28 ubiquitin ligase promotes MYC ‐driven transcription and tumourigenesis and predicts poor survival in breast cancer

Published:2013-06-14 Issue:7 Volume:5 Page:1067-1086
ISSN:1757-4676
Container-title:EMBO Molecular Medicine
language:en
Short-container-title:EMBO Mol Med

Author:

Cepeda Diana¹²,Ng Hwee‐Fang¹,Sharifi Hamid Reza³,Mahmoudi Salah¹,Cerrato Vanessa Soto⁴,Fredlund Erik³,Magnusson Kristina⁵,Nilsson Helén³,Malyukova Alena¹²,Rantala Juha⁶,Klevebring Daniel⁷,Viñals Francesc⁸,Bhaskaran Nimesh¹,Zakaria Siti Mariam³,Rahmanto Aldwin Suryo¹,Grotegut Stefan⁹,Nielsen Michael Lund¹⁰,Szigyarto Cristina Al‐Khalili¹¹,Sun Dahui⁹,Lerner Mikael²,Navani Sanjay⁵,Widschwendter Martin¹²,Uhlén Mathias¹¹,Jirström Karin¹³,Pontén Fredrik⁵,Wohlschlegel James¹⁴,Grandér Dan²,Spruck Charles⁹,Larsson Lars‐Gunnar³,Sangfelt Olle¹²

Affiliation:

1. Department of Cell and Molecular BiologyKarolinska InstitutetStockholmSweden

2. Department of Oncology/PathologyCancercentrum Karolinska, Karolinska InstitutetStockholmSweden

3. Department of MicrobiologyTumor and Cell Biology, Karolinska InstitutetStockholmSweden

4. Cancer Cell Biology Research Group, Department of Pathology and Experimental TherapeuticsFaculty of Medicine, University of BarcelonaBarcelonaSpain

5. Department of ImmunologyGenetics and Pathology, Rudbeck Laboratory, Uppsala UniversityUppsalaSweden

6. Oregon Health and Science University, Knight Cancer InstitutePortlandORUSA

7. Department of Medical Epidemiology and BiostatisticsKarolinska InstitutetStockholmSweden

8. Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, L'Hospitalet de Llobregat; and Physiological Sciences II DepartmentBellvitge Campus, University of BarcelonaSpain

9. Sanford‐Burnham Medical Research InstituteLa JollaCAUSA

10. NNF Center for Protein ResearchFaculty of Health SciencesCopenhagenDenmark

11. Department of BiotechnologyKTH/Alba Nova University CenterStockholmSweden

12. Department of Women's CancerUCL Elizabeth Garrett Anderson Institute for Women's Health, University College LondonUnited Kingdom

13. Department of Laboratory MedicineCenter for Molecular Pathology, Lund University, Skåne University HospitalLundSweden

14. Department of Biological ChemistryDavid Geffen School of Medicine, University of CaliforniaLos AngelesCAUSA

Publisher

EMBO

Subject

Molecular Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/emmm.201202341

Reference51 articles.

1. Transcriptional regulation and transformation by Myc proteins

2. The Ubiquitin Ligase HectH9 Regulates Transcriptional Activation by Myc and Is Essential for Tumor Cell Proliferation

3. SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box

4. Aberrant ubiquitin-mediatedproteolysis of cell cycle regulatory proteins and oncogenesis

5. Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins

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