β‐Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

Author:

Cai Jun1,Qi Xiaoping1,Kociok Norbert2,Skosyrski Sergej2,Emilio Alonso1,Ruan Qing1,Han Song3,Liu Li4,Chen Zhijuan1,Bowes Rickman Catherine5,Golde Todd6,Grant Maria B.4,Saftig Paul7,Serneels Lutgarde89,de Strooper Bart89,Joussen Antonia M.2,Boulton Michael E.1

Affiliation:

1. Department of Anatomy & Cell Biology, University of Florida, Gainesville, FL, USA

2. Department of Ophthalmology, Charité Universitätsmedizin Berlin, Berlin, Germany

3. Department of Surgery, University of Florida, Gainesville, FL, USA

4. Department of Pharmacology & Therapeutics, University of Florida, Gainesville, FL, USA

5. Department of Ophthalmology & of Cell Biology, Duke University Medical Center, Durham, NC, USA

6. Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA

7. Biochemical Institute, Christian‐Albrecht's University, Kiel, Germany

8. Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases (LIND), KU Leuven, Leuven, Belgium

9. VIB Center for the Biology of Disease, Vlaams Instituut voor Biotechnologie, Leuven, Belgium

Publisher

EMBO

Subject

Molecular Medicine

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