The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival

Author:

Hohenauer Tobias1,Berking Carola1,Schmidt Andreas23,Haferkamp Sebastian4,Senft Daniela1,Kammerbauer Claudia1,Fraschka Sabine1,Graf Saskia Anna1,Irmler Martin5,Beckers Johannes56,Flaig Michael1,Aigner Achim7,Höbel Sabrina7,Hoffmann Franziska23,Hermeking Heiko8,Rothenfusser Simon239,Endres Stefan23,Ruzicka Thomas1,Besch Robert1

Affiliation:

1. Department of Dermatology and Allergology, Ludwig‐Maximilian University, Munich, Germany

2. Division of Clinical Pharmacology, Department of Internal Medicine, Ludwig‐Maximilian University, Munich, Germany

3. Center of Integrated Protein Science CIPS‐M at the Division of Clinical Pharmacology, Department of Internal Medicine, Ludwig‐Maximilian University, Munich, Germany

4. Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany

5. Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics, Neuherberg, Germany

6. Technical University Munich, Center of Life and Food Sciences Weihenstephan, Freising, Germany

7. Institute of Pharmacology, Philipps‐University, Faculty of Medicine, Marburg, Germany

8. Experimental and Molecular Pathology, Institute of Pathology, Ludwig‐Maximilian University, Munich, Germany

9. Section of Gastroenterology and Endocrinology, Medizinische Klinik Innenstadt, Ludwig‐Maximilian University, Munich, Germany

Publisher

EMBO

Subject

Molecular Medicine

Reference48 articles.

1. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

2. Transforming growth factor‐beta1 increases survival of human melanoma through stroma remodeling;Berking C;Cancer Res,2001

3. Inhibition of urokinase-type plasminogen activator receptor induces apoptosis in melanoma cells by activation of p53

4. Proapoptotic signaling induced by RIG‐I and MDA‐5 results in type I interferon‐independent apoptosis in human melanoma cells;Besch R;J Clin Invest,2009

5. The closely related POU family transcription factors Brn-3a and Brn-3b are expressed in distinct cell types in the testis

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