Eosinophilic plastic bronchitis: Case series and review of the literature

Author:

Gipsman Alexander I.1ORCID,Feld Lance1,Johnson Brandy1ORCID,Needleman Joshua P.2,Boas Heather1,Lin Nancy13,DePasquale Brittany4,Pogoriler Jennifer35,McDowell Karen M.6,Piccione Joseph C.13

Affiliation:

1. Division of Pulmonary and Sleep Medicine Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

2. Pediatric Pulmonary Medicine Maimonides Medical Center Brooklyn New York USA

3. Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA

4. Office of the Medical Investigator Albuquerque New Mexico USA

5. Department of Pathology and Laboratory Medicine Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

6. Division of Pulmonary Medicine Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA

Abstract

AbstractPlastic bronchitis is a term used to describe group of life‐threatening disorders characterized by the presence of large obstructing casts in the airways. Eosinophilic plastic bronchitis is a subtype of plastic bronchitis that occurs mainly in children and has not been well‐described in the literature. Patients may have a history of asthma or atopy, but many do not. They often present with cough and wheezing, and frequently have complete collapse of one lung seen on imaging. The severity of presentation varies depending on the location of the casts, ranging from mild symptoms to severe airway obstruction and death. Bronchoscopy is often required to both diagnose and treat this condition. A variety of medical therapies have been used, although no formal studies have evaluated their efficacy. Symptoms may resolve after initial cast removal, but in some patients, cast formation recurs. Here, we report a case series of nine patients with eosinophilic plastic bronchitis and review the existing literature of this condition.

Publisher

Wiley

Subject

Pulmonary and Respiratory Medicine,Pediatrics, Perinatology and Child Health

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Eosinophilic mucus diseases;Allergology International;2024-07

2. Plastic bronchitis: Casting a wider net;Pediatric Pulmonology;2023-09-26

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