Affiliation:
1. C. B. Patel Computer College and J. N. M. Patel Science College Veer Narmad South Gujarat University Surat Gujarat India
2. Department of Pharmaceutical Chemistry Prof Ravindra Nikam College of Pharmacy Gondur Maharashtra India
3. R C Patel Institute of Pharmaceutical Education and Research Shirpur Maharashtra India
4. Laboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica Instituto Politécnico Nacional Ciudad de Mexico Mexico
Abstract
AbstractIsonicotinohydrazide is the first‐line medication in the prevention and treatment of tuberculosis. Antitubercular, antibacterial, antifungal, antiviral, anti‐inflammatory, antimalarial activity, anticancer, antineoplastic activity, and anti‐HIV activity are all demonstrated by drugs with a pyrimidine ring. The current study focuses on the synthesis of N‐(4‐(substituted‐phenyl)‐6‐(substituted‐aryl) pyrimidin‐2‐yl)‐2‐(2‐isonicotinoylhydrazinyl) acetamide from isonicotinohydrazide. Newly synthesized compounds were characterized by spectral studies (IR, 1H‐NMR, 13C‐NMR, and mass spectroscopy). They were screened for their antituberculosis, antimalarial, and antiprotozoal activities and compared with standard drugs. Molecular docking of isonicotinohydrazide‐bearing pyrimidine motifs was also done for some of the active compounds.
Subject
Health, Toxicology and Mutagenesis,Toxicology,Molecular Biology,Molecular Medicine,Biochemistry,General Medicine