Demonstration of the first‐pass metabolism in the skin of the hair dye, 4‐amino‐2‐hydroxytoluene, using the Chip2 skin–liver microphysiological model-Reference-Cited by-同舟云学术

Demonstration of the first‐pass metabolism in the skin of the hair dye, 4‐amino‐2‐hydroxytoluene, using the Chip2 skin–liver microphysiological model

Published:2021-02-17 Issue:10 Volume:41 Page:1553-1567
ISSN:0260-437X
Container-title:Journal of Applied Toxicology
language:en
Short-container-title:J Appl Toxicol

Author:

Tao Thi Phuong¹^ORCID,Brandmair Katrin²^ORCID,Gerlach Silke²,Przibilla Julia³,Géniès Camille⁴,Jacques‐Jamin Carine⁴,Schepky Andreas²^ORCID,Marx Uwe¹,Hewitt Nicola J.⁵^ORCID,Maschmeyer Ilka¹^ORCID,Kühnl Jochen²^ORCID

Affiliation:

1. Contract development TissUse GmbH Berlin Germany

2. Front End Innovation, department of toxicology Beiersdorf AG Hamburg Germany

3. ADMET & in vitro Pharmacology Pharmacelsus GmbH Saarbrücken Germany

4. Department of applied research: pharmacology Pierre Fabre Dermo‐Cosmétique Toulouse France

5. ADME Task Force Cosmetics Europe Auderghem Belgium

Publisher

Wiley

Subject

Toxicology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jat.4146

Reference24 articles.

1. Skin models for the testing of transdermal drugs

2. Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

3. Modern Prodrug Design for Targeted Oral Drug Delivery

4. Use of human liver and EpiSkin™ S9 subcellular fractions as a screening assays to compare the in vitro hepatic and dermal metabolism of 47 cosmetics‐relevant chemicals

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