Design, synthesis and biological evaluation of 2,4-diamino-6-methyl-5-substitutedpyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors
Author:
Publisher
Wiley
Subject
Organic Chemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/jhet.5570420418/fullpdf
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1. PTSA-Catalyzed Cyclization of 6-Aminouracils with Diimines: Efficient Synthesis of Functionalized Tetrahydropyrimido[4,5-d ]pyrimidine-2,4-diones;ChemistrySelect;2018-11-08
2. Synthesis of fused pyrrolo[3,4-d]tetrahydropyrimidine derivatives by proline-catalyzed multicomponent reaction;Tetrahedron;2014-07
3. Synthesis and biological activity of N4-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents;Bioorganic & Medicinal Chemistry;2010-05
4. CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6–5 fused ring system using the all-orientation search (AOS) routine and a modified cross-validated r2-guided region selection (q2-GRS) routine and its initial application;Bioorganic & Medicinal Chemistry;2010-02
5. 2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors;Bioorganic & Medicinal Chemistry;2010-01
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