1. In addition to the well known activity of the quinine alkaloids, biological activities have been reported for quinuelidine hydrochloride, 4-phenylquinuclidine, and a number of aminoalkylquinuclidinium salts (1). The quinuclidine system is thus of interest in the empirical approach to the synthesis of novel pharmaceutical agents.
2. Obtained from Aldrich Chemical Co., Inc., Milwaukee, Wisconsin.
3. Private communication from R. P. Williams, V. J. Bauer, and S. R. Safir.