Surgical outcomes of profunda artery perforator flap in head and neck reconstruction: A systematic review and meta‐analysis

Author:

Marchi Filippo12ORCID,Iandelli Andrea1ORCID,Pace Gian Marco34ORCID,Bellini Elisa12ORCID,Tirrito Alessandro12,Costantino Andrea5ORCID,Cerri Luca34,Greco Antonio6,Polimeni Antonella7,Parrinello Giampiero1,Peretti Giorgio12,De Virgilio Armando6ORCID

Affiliation:

1. IRCCS Ospedale Policlinico San Martino Genoa Italy

2. Department of Surgical Sciences and Integrated Diagnostics (DISC) University of Genova Genoa Italy

3. Department of Biomedical Sciences Humanitas University Milan Italy

4. Otorhinolaryngology Unit IRCCS Humanitas Research Hospital Milan Italy

5. Department of Otolaryngology – Head and Neck Surgery AdventHealth Orlando Celebration Florida USA

6. Department of Sensory Organs Sapienza University of Rome Rome Italy

7. Department of Odontostomatological and Maxillofacial Sciences Sapienza University of Rome Rome Italy

Abstract

AbstractObjectiveThis study aims to evaluate the efficacy of the profunda artery perforator (PAP) flap in head and neck reconstruction.MethodsA single arm meta‐analysis was performed for flap survival rate (primary outcome), reoperation for major complication, and overall complication rates (secondary outcomes).ResultsThe search strategy yielded a total of 295 potentially relevant publications, of which 13 were included. A total of 305 patients (males: 80.8%, n = 232/281), with a median age of 56.1 years (n = 305/305; 95% CI 53.9–63), who underwent a total of 307 PAP flap reconstructions for head and neck defects were included. Flap survival rate was 100% (n = 306/307; 95% CI 99.6%–100%), with a reoperation rate for major complications of 3.7% (n = 15/307; 95% CI 1.85%–6.1%) and an overall complication rate of 26.5% (n = 92/307; 95% CI 15.7%–38.9%). Notable postoperative complications included wound dehiscence (n = 15/307, 4.9%), delayed healing (n = 14/307, 4.6%), and wound infection (n = 12/307, 3.9%). Partial flap necrosis and hematoma occurred in 2.6% of cases (n = 8/307), while arterial and venous thrombosis were documented in 0.7% (n = 2/307) and 1.3%, respectively (n = 4/307).ConclusionThe application of the PAP flap in head and neck reconstructions showed several favorable aspects, such as an exceptionally low flap failure rate, versatility in achieving variable dimensions, and a relatively low incidence of complications. PAP flap might be considered as a compelling alternative to the traditionally employed soft tissue free flaps in head and neck reconstruction.

Publisher

Wiley

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