Affiliation:
1. Department of Chemistry Beijing Key Laboratory for Green Catalysis and Separation Center of Excellence for Environmental Safety and Biological Effects Beijing University of Technology Beijing China
2. Department of Chemistry School of Natural Sciences Institution Shiv Nadar Institution of Eminence (SNIoE) Greater Noida Uttar Pradesh India
3. Faculty of Mechanical and Energy Engineering Beijing University of Technology Beijing China
Abstract
AbstractHepatitis and arthritis are prevalent inflammatory diseases, and the utilization of fluorogenic probes incorporating hydrogen sulfide (H2S) as a crucial mediator of inflammation presents significant opportunities for early detection. However, the poor in vivo biodistribution and limited targeted efficacy of molecule probes for inflammation imaging severely impede their ability to differentiate the extent of inflammation and provide real‐time monitoring of inflammatory levels. Therefore, we developed a highly efficient H2S‐activated near‐infrared (NIR) fluorogenic probe (hCy‐DNP) for real‐time tracking and capturing fluctuations in H2S levels within inflammatory lesions. hCy‐DNP demonstrates an exceptionally sensitive fluorescence response to H2S expression, enabling specific differentiation between various levels of lipopolysaccharide (LPS) ‐stimulated early hepatitis models in situ, while also facilitating visual monitoring for diagnosis and efficacy evaluation of arthritis. Therefore, hCy‐DNP offers an innovative tool for exploring early diagnosis and evaluating treatment effectiveness across diverse inflammatory diseases.
Funder
National Natural Science Foundation of China