Phase 1 Study of ABT‐751 in Combination With CAPIRI (Capecitabine and Irinotecan) and Bevacizumab in Patients With Advanced Colorectal Cancer

Author:

Rudek Michelle A.1,Dasari Arvind2,Laheru Daniel1,He Ping1,Jin Runyan1,Walker Rosalind1,Taylor Gretchen E.1,Jimeno Antonio12,Donehower Ross C.1,Hidalgo Manuel13,Messersmith Wells A.12,Purcell W. Thomas12

Affiliation:

1. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University Baltimore MD USA

2. University of Colorado Cancer Center Denver CO USA

3. Centro Integral Oncologico Clara Campal Madrid Spain

Funder

Analytical Pharmacology Core of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference33 articles.

1. Cancer statistics, 2010;Jemal A;CA,2010

2. Microtubule Dynamics: Mechanism, Regulation, and Function

3. Pharmacokinetics of orally administered ABT-751 in children with neuroblastoma and other solid tumors

4. Tumor selective antivascular effects of the novel antimitotic compound ABT-751: an in vivo rat regional hemodynamic study

5. Mechanism of action of E7010, an orally active sulfonamide antitumor agent: inhibition of mitosis by binding to the colchicine site of tubulin;Yoshimatsu K;Cancer Res,1997

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